Is it one of the first steps to evaluate your state of health and your proclivity for developing age-related diseases?
Telomeres shorten after every chromosome replication. When telomeres are so short that replication of the cell may no be done with integrity, there will start entering into senescence replication, which leads to apoptosis of the cell, and the replication stops! Each cell has a limit: the Hayflick limit that establishes the established number of cellular division, which means that this number is between 50 to 70 times replication!
In order to have a better representation of what happening, a fetus may have between 15 kb to 20 kb pairs
By birth, this number reduced from 10 to 15 kb and then to reduce homogeneitically from 100 hundred to several hundred pairs each year
Telomeres enter in a short zone when then are under 3 kb!
Speaking of health and life expectancy, we have 2 parameters that matter the most :
1) Percentage of critically short telomeres
2) The degree reached by telomere attrition
The greatest value is in obtaining serial measurements and incorporating an annual health status by measuring Telomeres.